Cortical circuit alterations precede motor impairments in Huntington’s disease mice

Sleep Physiology Alterations Precede Plethoric Phenotypic Changes in R6/1 Huntington’s Disease Mice

In hereditary neurodegenerative Huntington's disease (HD), there exists a growing consideration that sleep and circadian dysregulations may be important symptoms. It is not known, however, whether sleep abnormalities contribute to other behavioral deficits in HD patients and mouse models. To determine the precise chronology for sleep physiology alterations and other sensory, motor, psychiatric ...

A circuit for motor cortical modulation of auditory cortical activity.

Normal hearing depends on the ability to distinguish self-generated sounds from other sounds, and this ability is thought to involve neural circuits that convey copies of motor command signals to various levels of the auditory system. Although such interactions at the cortical level are believed to facilitate auditory comprehension during movements and drive auditory hallucinations in pathologi...

Visuo-Motor Coordination Deficits and Motor Impairments in Parkinson's Disease

BACKGROUND Visuo-motor coordination (VMC) requires normal cognitive executive functionality, an ability to transform visual inputs into movement plans and motor-execution skills, all of which are known to be impaired in Parkinson's disease (PD). Not surprisingly, a VMC deficit in PD is well documented. Still, it is not known how this deficit relates to motor symptoms that are assessed routinely...

Applying Bioinfomatics Strategies in Huntingtons Disease Research

A Motor Cortical Contribution to the Anticipatory Postural Adjustments That Precede Reaching in Running Title: Motor Cortical Control of Posture

240 words 28 Text Pages: 51 29 Total figures: 13 (including 2 Appendix figures) 30 Black and white figures: 8 31 Color figures: 5 32 Tables: 2 33 34 Articles in PresS. J Neurophysiol (May 20, 2009). doi:10.1152/jn.00042.2009 Copyright © 2009 by the American Physiological Society. Yakovenko & Drew Motor cortical control of posture May 14, 2009 Page 2 Abstract 35 36 We tested the hypothesis that ...